Gas station without pumps

2018 December 26

Dante Labs is probably not a scam

Filed under: Uncategorized — gasstationwithoutpumps @ 15:51
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As readers may remember from Spit kit sent, I spent $500 in March 2018 in an attempt to get my genome sequenced through Dante Labs. I worried at the time that their price was too low for current sequencing capabilities, but I thought that I’d give them a try.

I am now convinced that Dante Labs is indeed a scam. (Update: 2019 March 15—I’m an no longer convinced one way or the other.  They have, finally, sent me the promised data.)

On 2018 August 31, they sent me an e-mail:

Your Raw Data are ready!

Dear Customer, 

We’re excited to let you know that we completed the sequencing of your sample. 

Over a month later, I asked when I would get the data they claimed to have.  On 2018 Oct 9, they sent me an e-mail:

Dear Kevin,
we apologize for this delay.
Your hard disk is among the next few to be shipped.
Again, we are sorry for this inconvenience.
Best regards,
Paul
Dante Labs
It is now four months since they claimed to have data for me, and almost three months since they claimed that mine was “among the next few to be shipped”.
It is clear now that they are incapable of delivering the whole genome sequence that they promised.  I suspect that they are doing a variant of a Ponzi scheme, where they use the money of new customers to pay for sequencing of a few select early customers, so that they don’t have all their customers complaining about non-delivery.
For my part, I’ve given up on ever expecting anything from them—now I have to decide if it is worthwhile to report them to the Better Business Bureau and appropriate district attorneys.  I can, at least, warn all my readers not to do business with them.
I’ll also have to look for a different, more reputable business to get my whole-genome sequencing done.  While I’m looking, I wonder whether it would be worth the $200 for a SNP panel from 23andme—that would not answer the most interesting question for me (the genetic cause of our family’s inherited bradycardia), but it might provide some data of interest.
If anyone has suggestions for whole-genome sequencing companies I should check, please let me know.

UPDATE: 2019 March 8.  Dante Labs informed me today that my data “has been ready for a while” and there is indeed a VCF report for me on their web site (with an 2018 August 11 date on it, though I don’t believe it was there then).   They had promised me the raw data, which they never sent.

I will check the VCF file to see whether it is consistent with 23andme data for me, and see whether Promethease can process the data (there is mention on the Promethease website that they have had trouble with Dante Labs data, though no reasons are given).  I have also ordered another whole-genome sequencing from fullgenomes.com, which I will also check for consistency.

If the VCF file for Dante Labs turns out to be correct and usable, I will remove the accusation of “scam” and just say that their customer service is terrible.

UPDATE: 2019 Mar 15.  The hard disk with the FASTQ and and alignment files (the raw data Dante Labs promised me last year) arrived yesterday.  After I catch up with my grading (only 51 more hours to go—10 hours more grading on Lab 5, then 41 hours of grading on Lab 6, which comes in on Monday), I’ll be consulting with the experts at UCSC about the best way to re-analyze the data.

Promethease had no trouble processing the VCF file from Dante Labs, but their analysis assumed that any variant not mentioned vas not tested, while most were sequenced but homozygous for the reference allele.  There needs to be a better format for communicating genotypes!

The preliminary results from the Promethease analysis are compatible with the 23andme data, but I’ll need to write a Python program to compare the 23andme genotype with the VCF file to see how much they differ.  This may be a bit tricky, as I’ll probably first have to create a 23andme reference, so that I can guess what the genotype is where the VCF has no variant reported or remove from the comparison any places where my 23andme genotype matches the reference.  Again, this will have to wait until my grading is done.

Right now, I am cautiously optimistic that Dante Labs is not a scam—though their delays in delivering data are not real encouraging.   If they really deliver whole-genome data at scale at the prices they are currently charging, I’ll be impressed.  If they are only delivering to a few selected customers, then not so impressed.

If the data checks out ok, I will have some of my relatives send samples to Dante Labs for sequencing—the prices is so much lower that it is worth some risk.

72 Comments »

  1. Do you worry about others having access to your genetic info and/or the chances of non-authorized people having that info?

    Comment by physicsmathmom — 2018 December 27 @ 13:05 | Reply

    • I don’t worry about genomic privacy very much—I’ve even considered joining one of the project that does free sequencing in return for fairly public access to the data, but they required travel to Boston, which was a deal breaker.

      The only people likely to cause me harm by knowing my genomic information are insurance companies, and their power to cause harm is not increased much by the knowledge.

      Comment by gasstationwithoutpumps — 2018 December 27 @ 13:12 | Reply

  2. What about charge-backing the credit card transaction? It doesn’t help with getting them prosecuted, but probably will help with putting them out of business. And you get your money back.

    Comment by plam — 2018 December 29 @ 16:11 | Reply

    • Unfortunately, the Dante Labs payment was done with my Wells Fargo debit card, and I have closed my Wells Fargo account, so there is no reasonable way to try to reverse the charge.

      Comment by gasstationwithoutpumps — 2018 December 29 @ 21:56 | Reply

  3. Thank you for publishing your story about Dante Labs. I have had a similar experience, and the public needs to be warned about this company and its too-good-to-be-true price for supposed whole genome sequencing. It is a scam. Dante Labs is taking consumers’ money for test results that they cannot, or will not, deliver.

    I purchased the whole genome sequencing test in July 2018. The kit arrived without a return shipping label—a problem that they have had repeatedly. While I was able to resolve this issue, it was just a sign of the difficulties to come.
    Dante’s website, now and at the time of my order, has claimed that they provide results in “about 10 weeks.” This is false, and they know it is false. Measuring from the day in July that I sent my test kit in, Dante Labs took 2 weeks to confirm that the kit was received and 4 ½ weeks to confirm that they had extracted the DNA and would start sequencing “as soon as possible.” At 12 weeks (mid-October) I emailed Dante labs requesting an update and was told I would have results in “early to mid November.” At 18 weeks (late November) I contacted them again and was told it would be “the end of December.” At 21 weeks, I asked again and the delivery date was bumped again, now to “mid January.” As I write this review it is mid-January, 25 weeks since I sent the test kit, and my results are not available.
    Having read more reviews and customer stories online, my experience is not at all unique, and I now seriously doubt that I will ever receive any genome sequencing results or a refund. If the company ever had legitimate intentions, they have been abandoned for a cash grab. Dante Labs continues to run unbeatable, cut-rate sales on their products to bring more money in while they provide nothing to existing customers who have been waiting 4 months, 6 months, 9 months, or longer and have received nothing.
    An honest company would proactively tell its customers when there are significant delays, provide realistic timelines it can meet, and change its website when it is clear that it cannot meet a supposed 10-week turn-around time. A reputable company would keep its promises. Dante Labs has done none of this, choosing instead to string along its existing customers and lure new customers with false claims. I don’t know if these big sales for prime day, black Friday, etc. are designed to generate enough cash to finish a few old orders from their backlog and maintain the illusion of functionality, to pad their revenue numbers to attract investors, or simply to cash out before the mounting negative reviews catch up with the company. What I do know is that what Dante Labs is promoting is a lie.
    The actions of Dante Labs are irresponsible and dangerous. Dante Labs knows that a significant part of its customer base, the people searching for information about their complete genome, are doing this because they have medical concerns or a family history of disease. These customers are relying on Dante Labs to give them data that provides insight on important and personal matters. For months, I’ve checked the website almost every day, hoping to simply receive what I bought from Dante Labs. I haven’t. It’s not just that Dante Labs has taken my money, it’s that they have made me hope for something that will not come and wasted months of my time. I will need to start all over again with a different company, and am months away from getting the information I was supposed to receive four months ago.
    No one should buy testing services from Dante Labs. It is an untrustworthy company that has never delivered what it promised to me and numerous other customers.
    If you do decide to use 23 and Me for testing, I would suggest you just purchase their cheaper ancestry test kit. The sequencing results are the same as the more expensive health kit and you can get the complete raw data either way. I purchased the health version, but did not find their health reports very useful. I found more accurate and comprehensive health data by running the raw data through Promethease and reviewing the information on SNPedia.
    Please let us know if you find a better sequencing service!

    Comment by *REDACTED* — 2019 January 15 @ 21:50 | Reply

    • Hi, Andrea from Dante Labs here. Can you please email me at andrea@dantelabs.com? I will look personally into your case. Obviously we are not a scam and accusations that we are a scam are baseless. Our mission is to make advanced genomics accessible to everyone. We have had delays last year, but we worked with every single use to solve these issues, especially delays, offering customized reports free of charge.

      Comment by Andrea Riposati — 2019 March 25 @ 17:45 | Reply

  4. I got my Dante labs results in 16 weeks. I’d emailed them after about 8 weeks to ask when I could expect the results. Their estimate was 3 weeks off, but I’m fine with that. I’d googled them already, so I knew a lot of people had had to wait more than 10 weeks, and so I was expecting that.

    Comment by TM — 2019 January 23 @ 17:55 | Reply

    • It is good to know that a few people are getting results from them, but that is consistent with a Ponzi scheme, which Dante Labs is looking a lot like.

      Comment by gasstationwithoutpumps — 2019 January 23 @ 18:07 | Reply

  5. I absolutely agree that Dante is a Ponzi scam. I bought four WGS kits for my family during the 2018 Prime Day sale. Order was placed via Amazon on July 21, 2018. Total was $1,396 ($349/kit). I work in a cancer biology lab that does a lot of sequencing, so I should have known better… this price was too low. But… There were reports of people getting their data, so I felt somewhat reassured.

    Like others, there was no return label, but I got them to reply to emails (at that time). They acknowledged receipt on August 7, 2018. They claimed “successful DNA extraction” on August 27, 2018. I contacted them on 10/23/2018 asking when I might expect the results (it had been 12 weeks, which was beyond what they initially promised). They said I would have results by mid-November. On December 18, I contacted them again and they said “they are working hard to complete the analysis by the end of the years”.

    I have not received any messages from Dante since (over 30 days and several emails) so I recently contacted Amazon and asked for my money back. It was a major struggle (to even get someone at amazon to understand what this product is and how it is supposed to work), but I did get a refund from amazon. Frustratingly, amazon still lists their products.

    I think Dante is way over the heads… either intentionally or not, they have become a Ponzi scheme. Their costs are too low and they need more and more customers to pay for the sequencing.

    I should have known better… I knew the cost was too low.

    As for legitimate sources for personal WGS use, a colleague used fullgenomes.com and was happy. The turnaround was 9 weeks, I believe he said. But the cost is MUCH higher. He did 30X WGS at $1300.

    Hopefully people considering Dante find this page — and avoid them at all costs. If you bought via amazon, it’s worth a try to get a refund…

    Comment by Matt — 2019 January 28 @ 06:44 | Reply

    • I ordered directly from Dante Labs, so I have no hope of getting either my data or a refund.

      Comment by gasstationwithoutpumps — 2019 January 28 @ 07:54 | Reply

    • Hi Matt, please send me an email (andrea@dantelabs.com) and I will look at your case.

      Thousands of people have received data and results. Claiming that we are a Ponzi Scheme or a scam is a serious accusation. We have had issues, including delays but we worked with every user to ensure that everyone receives their results, plus customized reports, free of charge.

      Thanks,

      Andrea

      Comment by andrea riposati — 2019 March 8 @ 02:04 | Reply

    • Hi Matt, Andrea from Dante Labs here. Please email me at andrea@dantelabs.com and I will look personally into your case. We are here to help. Our mission is to make advanced genomics accessible to everyone. We are attacked because we lowered the price below $1,000. Obviously we are not a scam and accusations that we are a scam are baseless. We have had delays last year, but we worked with every single use to solve these issues, especially delays, offering customized reports free of charge.

      Thanks

      Comment by Andrea Riposati — 2019 March 13 @ 03:04 | Reply

      • Well, Andrea, my sample was received at Dante Labs in MAY, and I still don’t have any results either, almost six months later. My sample has been “in quality control” for about five months. That does not seem reasonable.

        Comment by Dorn Hetzel — 2019 November 4 @ 04:54 | Reply

  6. Hi Matt,
    I found your blog while looking for information on Dantelabs; your experience was certainly very interesting. I work at a personal genomics startup Genebox (www.genebox.me) located in Dublin, Ireland; we provide direct-to-consumer whole genome sequencing at the depth 30x, secure data storage and a report on genetic disease risk; you can download a sample on the website. I understand you are primarily interested in getting the raw data which we can certainly arrange – we can provide FASTQ, BAM and VCF files. Our current promotion price is 1200 euros for the whole service. I admit we are quite an early stage company so the service delivery isn’t seamless as of yet, but based on our experience we can certainly guarantee delivery within 12 weeks. Please feel free to contact us at help@genebox.me for more information.

    Comment by Katja Rybakova — 2019 February 11 @ 08:15 | Reply

    • Matt is a commenter here—this is not his blog. I’ve added genebox.me to my list of possible vendors, though the prices is a littler higher than competitors like fullgenomes.com and veritasgenetics.com (Veritas Genetics doesn’t include the BAM file in their price, and does not give FASTQ at all)

      Comment by gasstationwithoutpumps — 2019 February 11 @ 09:33 | Reply

  7. Oh sorry, I misunderstood about the name. You are right that we are a bit more expensive, but in fairness our price is quite close to that of Fullgenomes and we do a lot of manual curation of literature before we decide to report a variant. We also do a deeper analysis for variants implicated in conditions of your interest, including for loss-of-function variants in relevant genes that are not present in the databases. Veritas Genetics, as you pointed out yourself, doesn’t provide actual raw data which limits research opportunities and only does standardized reporting without personalization. Let me know if you need any more information.

    Comment by Katja Rybakova — 2019 February 11 @ 12:51 | Reply

    • Katja, is it 1200 Euro or 3000 Euro ?

      Comment by Leon Kull — 2019 February 16 @ 16:16 | Reply

      • The website says 3000€, and that just includes the report and 1-year of genome data storage (nothing about delivering the full data set). That is a lot more expensive than other services.

        Comment by gasstationwithoutpumps — 2019 February 16 @ 23:04 | Reply

        • Not much different than the Full Genomes price (2900$) that’s the fair price for the 30x WGS test of the excellent quality.

          Comment by Leon Kull — 2019 February 17 @ 00:19 | Reply

          • The fullgenomes.com website has $2900 for Chromium linked-read whole genome. The 30× test, which seems the closest to what genebox.me offers, is listed at $1295, though the analysis costs an extra $250.

            The genebox.me site does not give details of the sequencing (other than it is Illumina), and does not say whether VCF, BAM, and FASTQ files are included—we only have Katja’s comment for that information. Apparently the 1200€ promotion is over—it must not have lasted long.

            Comment by gasstationwithoutpumps — 2019 February 17 @ 09:22 | Reply

            • Yes, correct !

              Comment by Leon Kull — 2019 February 17 @ 09:44 | Reply

            • One thing I don’t understand about the fullgenomes pricing is the lower-price 15× and 20× options. DNA sequencing cost should be roughly linear with coverage plus a fixed setup charge, so higher coverage should cost less per base, but the 15× option is much cheaper than the 30× option. If I just want the reads, it would seem to make more sense to buy the 15× twice ($1090 rather than $1295 for 30×) and merge the results (at the BAM or FASTQ level). That would not help most consumers, since the analysis to get the VCF file that gets interpreted relies on the higher coverage, but might make sense for me, since I was planning to redo the mapping and VCF generation anyway.

              Comment by gasstationwithoutpumps — 2019 February 17 @ 09:48 | Reply

              • The 15x and 20x whole genome options are entry level options for customers focused on ancestry. Ancestry results don’t require the same amount of data. That’s why they are discounted. However, there’s clearly an opportunity for prices to come down as the new technology from Illumina drives down costs.

                Comment by Justin Loe — 2019 February 17 @ 10:47

  8. […] the comments on Dante Labs is a scam, there has been some discussion on pricing of whole-genome sequencing.  There are a lot of […]

    Pingback by Full-genome sequencing pricing | Gas station without pumps — 2019 February 17 @ 12:23 | Reply

  9. Hi, sorry haven’t checked the blog for a couple of days. The price is indeed still 1200 euros (apologies for the confusion, there was a mistake on the buy it page – you can see now the price is still the one I mentioned at https://genebox.me/members#/join). Regarding the data it says in our T&C’s that you are entitled to get your data at any time with possible additional charges (which would apply if you wanted it on a hard drive but wouldn’t if you chose to download it directly from the storage platform). Some of our customers have downloaded the data already. If you would like to know more about sequencing please let me know.

    Comment by Katja Rybakova — 2019 February 19 @ 09:32 | Reply

  10. Hi – Andrea from Dante Labs here. Can you please present evidence that Dante Labs is a scam?

    Your case is a case where we made a mistake, you experienced delays. Some people experienced delays in 2018. Thousands of people received their data and reports.

    Claiming that we are a scam is a serious accusation. How do you reconcile that with the fact that people are actually receiving results?

    I am here to have a constructive discussion. I am confused why you make baseless accusations.

    Thanks,

    Andrea

    Comment by Andrea Riposati — 2019 March 8 @ 01:44 | Reply

  11. What about there more expensive tests they have…?

    Comment by Socrates — 2019 March 22 @ 13:39 | Reply

  12. I can confirm that:
    – Dante Labs delivers results in the end.
    – These results seem consistent with other results.
    – There are some customer service issues.

    So luckely, it seems not a scam and probably fully legitimate.

    Comment by Bart — 2019 March 25 @ 16:57 | Reply

  13. […] retract my former claim that Dante Labs is a scam with apologies to them—it appears that they just had very bad delivery times and poor customer […]

    Pingback by Comparing 23andme and Danta Labs data | Gas station without pumps — 2019 March 27 @ 06:22 | Reply

  14. […] retract my former claim that Dante Labs is a scam with apologies to them—it appears that they just had very bad delivery times and poor customer […]

    Pingback by Comparing 23andme and Dante Labs data | Gas station without pumps — 2019 March 31 @ 10:40 | Reply

  15. Dante Labs are liars, they’re saying “The first Long Reads Whole Genome Sequencing available commercially.”, but we all know that FullGenomes provides Long Reads WGS for more than a year.

    Comment by Leon Kull — 2019 April 8 @ 06:37 | Reply

    • Hi Leon,

      Andrea from Dante Labs here. Please correct me if I am wrong: FullGenomes uses Linked Reads Sequencing by 10X Genomics. Long reads are traditionally defined as PacBio or Oxford Nanopore.

      Also, in the sake of transparency, could you please verify if you have any association with FullGenomes?

      Thanks,

      Andrea

      Comment by Andrea Riposati from Dante Labs — 2019 April 8 @ 06:52 | Reply

      • Hello Andrea,

        I think the real question is whether the person who comments (you) has any qualifications in bioogy or genetics. You don’t have any whatsoever and to the best of my knowledge don’t have any training in this field. So, I’d recommend that if someone from your company is going to make a comment, it pretty well should be someone who has some sort of qualifications.

        From what I’ve seen your qualifications are in Economics and Business.
        My degree is in bioinformatics from Johns Hopkins University.

        Incidentally, Leon is our CTO at FGC.

        Best,

        Justin

        http://www.fullgenomes.com
        CEO

        Comment by Justin Loe — 2019 April 8 @ 13:00 | Reply

        • You said all that and then provided nothing to contradict her statement, as someone just shopping around looking for a test you just lost all confidence, especially with your shitty holier-than-thou attitude. Looks like I’ll be choosing between dante and veritas now.

          Comment by Faustus Lukas — 2019 May 2 @ 12:51 | Reply

          • Whatever

            Comment by Justin Loe — 2019 May 2 @ 13:20 | Reply

            • Lol, I’ll take that as confirmation that you do use 10x genomics which means she was right according to an article written by the Sanger Institute stating this regarding 10x genomics chromium system: “Whilst this is not technically a long-read sequencing technology, it is an important member of this ecosystem…” I doubt you can claim that they don’t have the relevant degrees to know what they’re talking about, also I can’t find 10x genomics claiming that their system is long-read. These may be functionally similar or the same but that does not make the claim by dante labs false, it seems to just say that you are the ones putting out false information. Please feel free to correct the record and not make a blatant appeal to authority.

              Comment by Faustus Lukas — 2019 May 2 @ 13:53 | Reply

              • 10x Genomics has more accurate SNP calling and in many instances better coverage of structural variants.

                Comment by Justin — 2019 May 2 @ 13:55

              • Incidentally, the error rate of the Nanopore technology is the primary reason why 95% of sequencing is done on Illumina platforms, and not Nanopore. For clinical or health purposes, Nanopore isn’t used 99% of the time.

                Those error rates are the major reason why Veritas, FGC, and other labs don’t offer Nanopore to consumers.

                Comment by Justin — 2019 May 2 @ 14:20

  16. Hi Andrea, I agree that transparency is important. Yes, I am with FullGenomes. And we in FullGenomes think that a fair play is also important. Why to spread fake news? It’not good not to you nor to your customers.
    Leon

    Comment by Leon Kull — 2019 April 9 @ 09:54 | Reply

  17. This company still appears to be a scam to me. What is a Ponzi scheme but a money making venture where some people do get money. In this case a few people are reportedly getting sequence results. My own experience tells me this is a scam. I have been waiting 6 months for results and only gotten evasive responses to my inquiries about the status of my sequence. I have tried contacting the company on 5 separate occasions and have no information to show for it. I have requested a full refund and am still waiting for a response. I think any reports of actual service are to keep the scam moving. I just hope that I can get some of my money back so I can go to a legitimate company for service. Dante Labs gives the entire industry a black eye.

    Comment by Andre — 2019 April 11 @ 10:24 | Reply

    • It could be a Ponzi scheme—if a few are getting sequenced but many are not, with the money from the many going to pay for the few. I have no evidence one way or the other on that. I now have my data and it looks fairly good, so I can’t complain about anything but the extreme slowness and poor customer service—but others may be getting very different experiences.

      Comment by gasstationwithoutpumps — 2019 April 11 @ 10:53 | Reply

      • Happy to demonstrate that we are not a Ponzi scheme. What type of evidence would you like to see?

        Also, again, accusing other organizations of being a Ponzi scheme is a very serious accusation. We are helping a lot of people accessing next generation sequencing at affordable prices. I would rather spend our time on data delivery than having to respond to these baseless accusations.

        Comment by Andrea Riposati — 2019 April 11 @ 11:10 | Reply

        • I think what people want to see is how many data sets have been delivered compared to the number ordered (with perhaps a 2-month delay between the counts. Having an outside auditor check the numbers (rather than just relying on self-reporting) would increase confidence. I realize that those numbers may be proprietary information, but an audit that reports how many data sets are delivered within 2 months of ordering might be convincing without being as revealing.

          People are rightly suspicious of biotech companies whose claims seem too good to be true—consider the Theranos scam, for example.

          The Dante Lab prices are substantially lower than other whole-genome sequencing, without a real explanation how the lower cost is achieved, so you have an uphill battle here. The simple explanation that many people reach for is that you are only delivering data to a small fraction of the customers. Proving that you are delivering to almost all customers (and refunding the ones where sequencing fails) would silence that critique.

          Comment by gasstationwithoutpumps — 2019 April 11 @ 13:33 | Reply

          • Thanks. I like your proposed approach. Also, we are now building our own sequencing center in Italy, so that we can sequence all samples internally and control the turnaround time. Right now, only the long reads whole genome is sequenced internally by us.

            Comment by Andrea Riposati - Dante Labs — 2019 April 12 @ 10:52 | Reply

  18. I feel people need to be warned about this company….
    1) The product was late. It is supposed to take “50 business days” per the website. It took 4 months and 20 days to get the results. When I did get the results…
    2) The product received was not as described. While the company might have changed the website and what they are currently selling, when I ordered the product there was a wellness and longevity kit with pharmaceutical measures and full genome sequencing. I ordered the more expensive full genome. Today, I received an email my results were available- I got a wellness and longevity report only. Excuse me, but what?! No, no, no…. that is incorrect. I expected to receive my full genome report as was described at the time that I purchased the kit- https://dnatestingchoice.com/en-us/dna-sequencing/provider/dante-labs/4479 How dare they try to send me the lesser report that costs much less money and try to play it off as the real report! This is unethical and fraud. They deserve to have their company reported for this.
    3) When I ordered my kit, the instructions of the website said to send an email requesting your customized report- I did and received a response back from their company confirming this. I never received my customized report. When I went to ask customer service, they told me I had to fill out the new online form and essentially go to the back of the line. That is not how this works. If you have one policy- you deal with all existing orders under that platform. You don’t change the rules midstream, not notify the client you changed, and not do what you already acknowledged you would do. I did fill out the special online form, but the fact that the company does not stand by its prior obligations speaks to the poor form and execution.

    As a medical doctor and researcher, I tried this site to see if it would be an added benefit in my practice. However, this experience has been nothing short of disastrous. I will not be recommending Dante Labs. Their poor performance and frankly unethical business practices just lost them a stream of referrals. I genuinely hope they are happy with lost business.

    Comment by Stephanie — 2019 April 12 @ 08:09 | Reply

  19. Hi Stephanie, please email me at andrea@dantelabs.com and I will look personally into your case. I can assure you will get all your data (VCF, etc.) and reports, including the Pharmacogenomics Report and the Customized Reports. I understand your frustration. I am confused by your language. We can keep the conversation civil.

    We are not “trying to play the wellness report as the real report”.

    Also, the core cost of sequencing your genome is in the sequencing. So, the “lesser report” is an additional cost, it does not generate cost savings. If anything we are spending more money by providing you with this report.

    We have worked with every single user on issues and data, providing customized reports free of charge and allowing people to access the whole genome way below $1,000. No reason to be concerned. You will receive your full data and reports.

    Thanks,

    Andrea

    Comment by Andrea Riposati from Dante Labs — 2019 April 12 @ 10:50 | Reply

    • I will be emailing you, but to be frank your message is disrespectful in itself. “We can keep the conversation civil”? I used no curse words at any point, therefore, this comment is inappropriate and, frankly, rude. If you are the face of the company, you need to do better.

      Comment by Stephanie — 2019 April 12 @ 11:47 | Reply

      • Apologies if my words offended you. It was not my intention. I look forward to being able to help you get your full results.

        Comment by Andrea Riposati — 2019 April 12 @ 11:48 | Reply

  20. Hi. Here is yet another unhappy customer (carefully avoiding the word “victim”) of Dante Labs. I am a researcher in biophysics. I was hoping to give the full genome sequences as a lifetime gift to my kids, and also perform some analyses on their WGS data in the future. Here is how it went:

    My order was confirmed on Nov 24, 2018. Almost 6 months passed since my purchase.
    I received the shipment order email on Jan 2, that is, 39 days after my payment.
    I sent the samples approximately three weeks after arrival.
    4 months of no progress with casual responses to my occasional inquiries.

    5. Two days ago, I asked for a refund. And voila, only 6 hours ago I learned that one of the two samples passed the quality check and the other didn’t (no wonder, after months of wait in a test tube!):

    We are currently running the sequencing process of your sample (60820188477672). You are expected to receive the final results by mid-July.

    The other kit: 60820188477707 did not qualify to pass the quality test. We’ll send you a new collection kit is a few days.

    4 months to inform about a failed quality screening?? In summary, half a year of wait and there is practically no progress. From my perspective this qualifies as a “scam”. In the best case it is a failed business but then, what is the difference for the customer?

    It is important that this discussion appears in the first page of a google search (I wish I had seen it earlier!). I urge all who have lost money to Dante Labs to make their voices heard on this platform or elsewhere. I will certainly do my share, starting today. And no, I am not involved with any rival company :)

    Alkan

    Comment by Alkan — 2019 May 14 @ 10:15 | Reply

  21. I sent my material in January, now June. There is not any result. Only e-mail assurances are available soon. I think these are scammers.

    Comment by Ilya Kazakov — 2019 June 6 @ 04:18 | Reply

    • Hi, Andrea from Dante Labs here. Your results are actually in your account. Please feel free to email me andrea at dantelabs.com if you have any questions

      Comment by andrea riposati — 2019 June 6 @ 07:23 | Reply

  22. My relatives have 3 orders in for whole-genome sequencing from Dante Labs (from the DNA Day sale). We’ll see whether they get timely service.

    My order of whole-genome sequencing from fullgenomes.com took about 1 month—substantially faster than from Dante Labs, but also more expensive. Once I get out from under my insane grading load (about 10 more days to do about 82–120 hours of grading), I’ll start comparing the results from the two sequencing runs, as well as comparing both with the genotyping by 23andme.

    Comment by gasstationwithoutpumps — 2019 June 6 @ 08:17 | Reply

  23. There are a small number of mostly negative reviews of Dante Labs at https://www.trustpilot.com/review/www.dantelabs.com
    The complaints seem to be non-delivery or very slow delivery of data.

    Comment by gasstationwithoutpumps — 2019 June 6 @ 09:30 | Reply

  24. […] fairly typical of the direct-to-consumer sequencing outfits.  (Dante Labs is much cheaper, but a number of people have been unhappy with the slow or non-delivery of […]

    Pingback by Comparing fullgenomes.com with Dante Labs | Gas station without pumps — 2019 June 18 @ 23:58 | Reply

  25. I ordered Dante Labs WGS for my mother and got the results after ca 4 months.
    Some questions for Dante Labs:
    Why do you use 10 years old reference genome (hg19)?
    Why does the whole genome vcf-file contain references for chrY and one entry of Y-chromosome SNP? Subject in question does not have an Y chromosome, to my knowledge.
    Chromesome X contains gaps with no SNP information. I have not checked other chromosomes..
    Is there any proof, that your DNA analysis is more than ˚23andme˚ plus some junk non-standard SNPs copied from some old hg19-vcf?

    Comment by Tom — 2019 June 23 @ 00:16 | Reply

    • I welcome a reply from Dante Labs, but I think I can answer some of these myself, because I had somewhat similar questions.
      1) hg19 or GRCh37 is used instead of the newer GRCh38, because most of the SNP annotation has been done relative to that older assembly. There have been “liftovers” to move the annotation to GRCh38, but there has not yet been much new development or correction of the SNP annotation on GRCh38. Some tools (like Promethease) can accept variant calls for either assembly (as long as it is clear which assembly), but some tools only know the GCRh37 coordinate system. I don’t know of any that understand only GRCh38.

      2)The algorithm for mapping reads sometimes mismaps them. There are regions of the X and Y chromosome that are homologous (having common ancestry, and hence almost identical in sequence). A mutation or sequencing error can make a region of the X chromosome look more like a region of the reference Y chromosome. If you do variant calling on a male genome, you will find a number of the X chromosome SNPs being called as diploid, as some of the Y reads gets mapped to the X. On a female genome some of the X gets mapped as Y, though less, as Y is a much smaller target for mismapping than X is.

      3) Every chromosome has lots of repeat regions (ALU elements, SINEs, LINEs, …)—half to 2/3 of the human genome consists of such repeats. If the repeats are of recent origin and so not heavily mutated as a result of normal neutral evolution, they can be identical at the 100bp or 150bp length of the reads of most sequencing technologies, and so mapping algorithms can’t tell where to map the reads. A lot of pipelines use tools like RepeatMasker to remove reads that map to repeat elements, as they are useless or actively misleading for variant detection. The result is that large regions of the genome may not have any reads mapped to them.

      4) Of the various reports I have looked at, 23andme, provides the best consumer-level reports. Promethease (which can accept variant calls from any of the genotyping vendors, including 23andme), does a thorough job reporting on everything found, with good pointers to the literature that the reports are based on, but their emphasis on including almost everything results in a lot of crap, and it can be hard to separate the interesting signal from stuff that is just noise. If you are only interested in SNP information that has been well validated, 23andme checks most of those SNPs and does so cheaply.

      Whole-genome sequencing is really only valuable if you are looking for idiosyncratic variants that are not on the 23andme DNA chip. (One research application of whole-genome sequencing is tumor/normal comparison for cancer patients, to try to determine the key pathways disrupted in the cancer, to look for therapeutic targets—every cancer is different and every patient is different, so it helps to have a tumor/normal pair for the patient.) The reports that Dante Labs provides are not particularly good, as they cover less than the 23andme reports, are harder to interpret, and don’t provide detailed citations that you can follow up on to see how solid the science is. I recommend spending the extra $12 to get a Promethease report as well.

      Comment by gasstationwithoutpumps — 2019 June 23 @ 09:23 | Reply

      • Thank you gasstationwithoutpumps for insight. Perhaps Dante Labs isn’t a scam after all (science-wise). However, their business model raises questions. Extremely low price (179 euros) for WGS can’t be a sustainable business practise, unless there’s some other ways to generate revenue with DNA data.

        Comment by Tom — 2019 July 3 @ 00:24 | Reply

        • Yes, they’re using fax, floppy disks and GRCh37…

          Comment by Leon Kull — 2019 July 3 @ 02:27 | Reply

          • Leon, there is no evidence that Dante Labs are using fax and floppy disks. GRCh37 is still an acceptable reference for SNP calling, as most of the literature still uses it. I wish that the research community would move over to GRCh38 and standardize on it, but that seems to be a very slow process—I don’t think that we can blame Dante Labs for following the crowd here—it was probably the result of using cheap software or a cheap service to keep prices down.

            Please confine your trash-talking of your competitors to true, verifiable assertions.

            I’ll be doing a comparison of your company’s results with Dante Labs results soon—it has been slowed down a bit by the difference in reference genomes (both Dante Labs and 23andme used GRCh37, while fullgenomes used GRCh38). I had variants called with a different software pipeline (DeepVariant) on both references for both data sets, but I’m having some difficulty making a clear summary of the results.

            Comment by gasstationwithoutpumps — 2019 July 3 @ 09:02 | Reply

            • That was a joke: “using fax and floppy disks.”

              You need to up your game in understanding humor, Kevin.

              Sincerely,

              Justin

              CEO

              Comment by Justin — 2019 July 3 @ 09:04 | Reply

              • It would be a great sign of progress if Dante Labs started using floppy disks and fax instead of pen and paper. Or maybe they use stone tablets w/ hammer & chisel? I have been waiting for just an update on the status of the kit I sent for months and I ordered November 25, 2018, over 7 months ago. I will send some smoke signals to them later today and see…

                Comment by Nick B — 2019 July 3 @ 09:14

              • A 7-month delay is ridiculously long and does support the notion that they are a Ponzi scheme. My relatives have orders from DNA Day (April 2019) for which there has been no progress yet.

                Comment by gasstationwithoutpumps — 2019 July 3 @ 09:19

              • I understood that it was intended to be a joke. I did not find it funny—insulting others by exaggerated lies is rarely funny.

                Perhaps your company needs to concentrate on technology and leave the humor to professionals—or confine your attempts at humor to the company Slack chat.

                I am still concerned about the possibility that Dante Labs is either burning up capital with no viable business plan (potentially cheating their investors) or running a Ponzi scheme (delivering to only a fraction of their customers). Evidence to support or refute these concerns is welcome.

                Comment by gasstationwithoutpumps — 2019 July 3 @ 09:15

        • I don’t know whether Dante Labs is a scam or not. They are either a scam or are burning through venture capital very quickly—the two business models are very hard to tell apart from the outside.

          Comment by gasstationwithoutpumps — 2019 July 3 @ 08:51 | Reply

          • There’s a difference between a joke and a “lie.” Commonly understood, it is a joke. Exaggerated lies are something entirely different.

            Comment by Justin Loe — 2019 July 3 @ 09:41 | Reply

  26. Dante Labs has an “F” rating with BBB (Better Business Bureau) which is the worst rating a company can get. It takes hard work and consistent lack of customer service to dig yourself down to an F rating with the BBB…

    Comment by Nick B — 2019 June 26 @ 02:56 | Reply

  27. Dante Labs has an F rating with BBB (Better Business Bureau), that’s the lowest rating a company can get. It takes hard work and consistent lack of customer service to dig yourself down to an F rating with the BBB…

    Comment by Nick B — 2019 June 26 @ 02:58 | Reply

  28. Sample received in Mar 6, still no results. Last email said end of July-mid August (previous one said end of June).
    Once (or if?) I receive it I will post here the date. I tried emailing Andrea a week ago but no response. Let’s hope for the best, I guess.

    Comment by Nilson Santos — 2019 July 16 @ 15:46 | Reply

    • September 29th: still no results. :(

      Comment by Nilson Santos — 2019 September 29 @ 12:39 | Reply

  29. Any update with your data? I finally did receive my raw data as well (just the online they give you in the deal, as I did not order the hard disk). I’m now wondering where to get this data analyzed. Especially if any website does it for free. This is my first time getting it sequenced so I’m pretty clueless here.
    Do you have any advise or suggestions?
    Also I got my data so so late, after I finally gave up they’re ever going to sequence it and thought my money had gone down the drain…

    Comment by aaasfh — 2019 July 27 @ 08:55 | Reply

    • The Promethease website gives you a very detailed report based on almost any genotyping data (vcf files from Dante Labes or fullgenomes, DNA chip data from 23and me, …) for about $12. The reports are not as consumer-friendly as 23andme reports, but cover a lot of things that 23andme does not look at (but not some of the proprietary stuff that 23andme has not published). It is much more complete than the analysis that Dante Labs provides, but does require a lot of digging to interpret.

      Promethease also allows you to provide multiple sources of information (23andme and whole-genome sequencing, for example). The resulting report can be used to highlight conflicts between the genotyping. So far, all the major findings have been in agreement between all three genotyping methods I used, but there are a number of conflicts between the whole-genome methods even in just the set of calls that 23andme makes. I’ve been considering pooling the fullgenomes and Dante Labs data to see if I can get more robust calls (the standard coverage is a little low, so there are a lot of weak calls).

      Comment by gasstationwithoutpumps — 2019 July 27 @ 10:47 | Reply

    • We at Full Genomes are accepting the DL data for analysis. See https://www.fullgenomes.com/analysis-and-more/

      Comment by Leon Kull — 2019 July 28 @ 00:17 | Reply


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